All-trans Retinoic Acid Upregufates Thrombomodulin and Downregulates Tissue-Factor Expression in Acute Promyelocytic Leukemia Cells: Distinct Expression of Thrombomodulin and Tissue Factor in Human Leukemic Cells
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چکیده
The expressions of thrombomodulin (TMI and tissue factor (TF) by all-trans retinoic acid (ATRAI were studied in human leukemic cell lines including NB4 (acute promyelocytic Ieukemia) and U937 (monoblastic leukemia). ATRA remarkably upregulated TM antigen expression in cell lysates as well as TM cofactor activity on the cell surfaces of NB4. The level of TM mRNA in NB4 mils was increased by ATRA. Inherently procoagulant NB4 cells contained markedly higher content of TF. which was efficiently reduced by ATRA. Modest increase of l“ and decrease of TF were observed when NB4
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تاریخ انتشار 2002